Protein Molecular Weight Markers
ABclonal Technology ADAM19 Rabbit pAb
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This member is a type I transmembrane protein and serves as a marker for dendritic cell differentiation. It has been demonstrated to be an active metalloproteinase, which may be involved in normal physiological processes such as cell migration, cell adhesion, cell-cell and cell-matrix interactions, and signal transduction. It is proposed to play a role in pathological processes, such as cancer, inflammatory diseases, renal diseases, and Alzheimers disease.
ABclonal Technology SRPRB Rabbit pAb
The protein encoded by this gene has similarity to mouse protein which is a subunit of the signal recognition particle receptor (SR). This subunit is a transmembrane GTPase belonging to the GTPase superfamily. It anchors alpha subunit, a peripheral membrane GTPase, to the ER membrane. SR is required for the cotranslational targeting of both secretory and membrane proteins to the ER membrane.
ABclonal Technology SLC34A3 Rabbit pAb
This gene encodes a member of SLC34A transporter family of proteins, and is expressed primarily in the kidney. It is involved in transporting phosphate into cells via sodium cotransport in the renal brush border membrane, and contributes to the maintenance of inorganic phosphate concentration in the kidney. Mutations in this gene are associated with hereditary hypophosphatemic rickets with hypercalciuria. Alternatively spliced transcript variants varying in the 5 UTR have been found for this gene.
ABclonal Technology BTF3 Rabbit pAb
This gene encodes the basic transcription factor 3. This protein forms a stable complex with RNA polymerase IIB and is required for transcriptional initiation. Alternative splicing results in multiple transcript variants encoding different isoforms. This gene has multiple pseudogenes.
Biotium Primary Antibody Neurofilament H rRmdO-20 CF740 1/EA
Neurofilament-H (rRmdO-20) is a recombinant mouse monoclonal antibody that recognizes Neurofilament-H This CF740 antibody conjugate has been validated in Immunofluorescence CF and reg dyes are Biotiums line of next-generation fluorescent dyes with advantages in brightness and photostability
ABclonal Technology MS4A7 Rabbit pAb
This gene encodes a member of the membrane-spanning 4A gene family, members of which are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns in hematopoietic cells and nonlymphoid tissues. This family member is associated with mature cellular function in the monocytic lineage, and it may be a component of a receptor complex involved in signal transduction. This gene is localized to 11q12, in a cluster of other family members. At least four alternatively spliced transcript variants encoding two distinct isoforms have been observed.
ABclonal Technology TAF1 Rabbit pAb
This gene encodes the largest subunit of TFIID, a basal transcription factor required for RNA polymerase II activity. TFIID binds to the core promoter to position the polymerase and assembles the transcription complex. It also serves as a channel for regulatory signals and interacts with activators and other regulators to influence transcription initiation. This subunit contains two protein kinase domains and has acetyltransferase activity, acting as a ubiquitin-activating/conjugating enzyme. Mutations in this gene cause Dystonia 3, torsion, X-linked, a dystonia-parkinsonism disorder. Alternative splicing results in multiple transcript variants, some sharing exons with TAF1 and additional downstream DYT3 exons.
ABclonal Technology ALDH1L2 Rabbit pAb
This gene encodes a member of both the aldehyde dehydrogenase superfamily and the formyl transferase superfamily. This member is the mitochondrial form of 10-formyltetrahydrofolate dehydrogenase (FDH), which converts 10-formyltetrahydrofolate to tetrahydrofolate and CO2 in an NADP(+)-dependent reaction, and plays an essential role in the distribution of one-carbon groups between the cytosolic and mitochondrial compartments of the cell. Alternatively spliced transcript variants have been found for this gene.
Meso Scale Discovery PhosphoThr231/Tau TTL20 Plate
The Meso Scale Discovery Phospho-Thr231/Total Tau Kit is a multiplex immunoassay kit that allows for the simultaneous measurement of phosphorylated Thr231 tau and total tau in biological samples such as CSF serum plasma cell lysates and brain homogenates The kit contains a 96-well plate coated with capture antibodies specific for phosphorylated Thr231 tau and total tau It utilizes MSD s electrochemiluminescence detection technology to provide sensitive and accurate quantification of both analytes from a single small sample volume The kit includes all necessary reagents and can process up to 80 samples in duplicate It is suitable for studying Alzheimer s disease and other tauopathies
ABclonal Technology Sterol carrier protein 2 Rabbit mAb
This gene encodes two proteins sterol carrier protein X (SCPx) and sterol carrier protein 2 (SCP2), as a result of transcription initiation from 2 independently regulated promoters. The transcript initiated from the proximal promoter encodes the longer SCPx protein, and the transcript initiated from the distal promoter encodes the shorter SCP2 protein, with the 2 proteins sharing a common C-terminus. Evidence suggests that the SCPx protein is a peroxisome-associated thiolase that is involved in the oxidation of branched chain fatty acids, while the SCP2 protein is thought to be an intracellular lipid transfer protein. This gene is highly expressed in organs involved in lipid metabolism, and may play a role in Zellweger syndrome, in which cells are deficient in peroxisomes and have impaired bile acid synthesis. Alternative splicing of this gene produces multiple transcript variants, some encoding different isoforms.
ABclonal Technology S100A5 Rabbit pAb
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein has a Ca2+ affinity 20- to 100-fold higher than the other S100 proteins studied under identical conditions. This protein also binds Zn2+ and Cu2+, and Cu2+ strongly which impairs the binding of Ca2+. This protein is expressed in very restricted regions of the adult brain.
ABclonal Technology PSD2 Rabbit pAb
Predicted to enable guanyl-nucleotide exchange factor activity and phospholipid binding activity. Predicted to be involved in regulation of ARF protein signal transduction and regulation of catalytic activity. Predicted to be located in cleavage furrow and ruffle membrane. Predicted to be active in glutamatergic synapse and postsynapse.
ABclonal Technology THUMPD3 Rabbit pAb
Predicted to enable tRNA (guanine) methyltransferase activity. Predicted to be involved in tRNA methylation. Located in cytosol and nucleolus.
ABclonal Technology COPG1 Rabbit pAb
Predicted to enable structural molecule activity. Predicted to be involved in several processes, including Golgi vesicle transport, establishment of Golgi localization, and organelle transport along microtubule. Located in Golgi apparatus.
ABclonal Technology LIPH Rabbit pAb
This gene encodes a membrane-bound member of the mammalian triglyceride lipase family. It catalyzes the production of 2-acyl lysophosphatidic acid (LPA), which is a lipid mediator with diverse biological properties that include platelet aggregation, smooth muscle contraction, and stimulation of cell proliferation and motility.